| Department of State | Secretary of State | 1789 |
| Department of the Treasury | Secretary of the Treasury | 1789 |
| Department of Defense | Secretary of Defense | 1947 |
| Department of Justice | Attorney General | 1870 |
| Department of the Interior | Secretary of the Interior | 1849 |
| Department of Agriculture | Secretary of Agriculture | 1862 |
| Department of Commerce | Secretary of Commerce | 1903 |
| Department of Labor | Secretary of Labor | 1913 |
| Department of Health and Human Services | Secretary of Health and Human Services | 1953 |
| Department of Housing and Urban Development | Secretary of Housing and Urban Development | 1965 |
| Department of Transportation | Secretary of Transportation | 1966 |
| Department of Energy | Secretary of Energy | 1977 |
| Department of Education | Secretary of Education | 1979 |
| Department of Veterans Affairs | Secretary of Veterans Affairs | 1989 |
| Department of Homeland Security | Secretary of Homeland Security | 2002 |